End Mass Effects on the Frequency Response of Cantilevers: Analytical Results

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Media Downloading, Uploading, and Sharing Among College Students

On many occasions over recent years the Recording Industry Association of America (RIAA) has made national headlines with its large-scale effort to launch civil suits against individuals alleged to be involved in illegal downloading of copyrighted material over the Internet including many college students. By reputation, college students are among the most active users of digital media obtained through peer-to-peer downloading and similar techniques. We conducted a three-phase study to understand student beliefs and behavior in the areas of media downloading, copyright, intellectual property ownership, and computing security. The research included a small cohort of personal interviews, an anonymous paper and pencil survey of 164 students, and a Web-based survey with 402 respondents

DALES: Automated Tool for Detection, Annotation, Labelling and Segmentation of Multiple Objects in Multi-Camera Video Streams

In this paper, we propose a new software tool called DALES to extract semantic information from multi-view videos based on the analysis of their visual content. Our system is fully automatic and is well suited for multi-camera environment. Once the multi-view video sequences are loaded into DALES, our software performs the detection, counting, and segmentation of the visual objects evolving in the provided video streams. Then, these objects of interest are processed in order to be labelled, and the related frames are thus annotated with the corresponding semantic content. Moreover, a textual script is automatically generated with the video annotations. DALES system shows excellent performance in terms of accuracy and computational speed and is robustly designed to ensure view synchronization

Long-lived non-thermal states realized by atom losses in one-dimensional quasi-condensates

We investigate the cooling produced by a loss process non selective in energy on a one-dimensional (1D) Bose gas with repulsive contact interactions in the quasi-condensate regime. By performing nonlinear classical field calculations for a homogeneous system, we show that the gas reaches a non-thermal state where different modes have acquired different temperatures. After losses have been turned off, this state is robust with respect to the nonlinear dynamics, described by the Gross-Pitaevskii equation. We argue that the integrability of the Gross-Pitaevskii equation is linked to the existence of such long-lived non-thermal states, and illustrate this by showing that such states are not supported within a non-integrable model of two coupled 1D gases of different masses. We go beyond a classical field analysis, taking into account the quantum noise introduced by the discreteness of losses, and show that the non-thermal state is still produced and its non-thermal character is even enhanced. Finally, we extend the discussion to gases trapped in a harmonic potential and present experimental observations of a long-lived non-thermal state within a trapped 1D quasi-condensate following an atom loss process

Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date.

Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the United States. Advances over the past 20 years in understanding the immune-mediated pathophysiology of psoriasis have led to the development of targeted biologic therapies for this condition. Currently, biologic medications approved for the treatment of plaque psoriasis include tumor necrosis factor α inhibitors, interleukin (IL)-17 or IL-17 receptor inhibitors, IL-12/23 inhibitors, and IL-23 inhibitors. Tildrakizumab-asmn is a monoclonal antibody that targets the p19 subunit of IL-23 and is approved for use in adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. This article reviews the current pharmacologic, efficacy, and safety data on tildrakizumab-asmn

Knowledge in the dark: scientific challenges and ways forward

A key dimension of our current era is Big Data, the rapid rise in produced data and information; a key frustration is that we are nonetheless living in an age of ignorance, as the real knowledge and understanding of people does not seem to be substantially increasing. This development has critical consequences, for example it limits the ability to find and apply effective solutions to pressing environmental and socioeconomic challenges. Here, we propose the concept of “knowledge in the dark”—or short: dark knowledge—and outline how it can help clarify key reasons for this development: (i) production of biased, erroneous, or fabricated data and information; (ii) inaccessibility and (iii) incomprehensibility of data and information; and (iv) loss of previous knowledge. Even in the academic realm, where financial interests are less pronounced than in the private sector, several factors lead to dark knowledge, that is they inhibit a more substantial increase in knowledge and understanding. We highlight four of these factors—loss of academic freedom, research biases, lack of reproducibility, and the Scientific tower of Babel—and offer ways to tackle them, for example establishing an international court of arbitration for research and developing advanced tools for research synthesis

Resonant Microcantilevers for the Determination of the Loss Modulus of Thin Polymer Films

The increasing interest in polymer materials creates the need for accurate tools to characterize their mechanical properties. Due to energy dissipation in polymers during deformation, these materials exhibit viscoelastic behavior. Accurate determination of these viscoelastic properties and, more specifically, viscous losses, remains challenging and mainly unknown for thin polymer films. In this paper, a straightforward method to determine the loss modulus of organic materials using resonating microcantilevers has been developed. The extracted results for polyisobutylene show the variation of viscous losses over a large range of frequencies (7-350 kHz)

Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges

Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are urgently required. One of the most exciting approaches to emerge from research on arthropods is the use of the endosymbiotic intracellular bacterium Wolbachia to control arbovirus transmission from mosquito to vertebrate. These α-proteobacteria propagate through insects, in part through modulation of host reproduction, thus ensuring spread through species and maintenance in nature. Since it was discovered that Wolbachia endosymbiosis inhibits insect virus replication in Drosophila species, these bacteria have also been shown to inhibit arbovirus replication and spread in mosquitoes. Importantly, it is not clear how these antiviral effects are mediated. This review will summarize recent work and discuss determinants of antiviral effectiveness that may differ between individual Wolbachia/vector/arbovirus interactions. We will also discuss the application of this approach to field settings and the associated risks